Interferon inducing activity of a 2'-modified doublestranded complex, poly(2'-azido-2'-deoxyinosinic acid) poly(cytidylic acid).
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چکیده
منابع مشابه
Inhibition of cancer cell growth by polyinosinic-polycytidylic acid/cationic liposome complex: a new biological activity.
A complex of polyinosinic-polycytidylic acid [poly(I) x poly(C)] and cationic liposome (LIC) inhibited the growth of many tumor cell lines at low concentration in vitro, but poly(I) x poly(C) alone had no such antiproliferative effect. The IC50 values of LIC against the tumor cells ranged from 0.1 to 1000 ng/ml. LIC had strong cytotoxic effects on malignant cells of epithelial and fibroblastic ...
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A study of the characteristics of the guanine-cytosine bond is important to the understanding of its contributions to the secondary structure of nucleic acids. However, such a study is very difficult to carry out with synthetic homopolymers because of the occurrence of stable self-bonded guanine structures (1). It is almost impossible to obtain polyriboguanylic acid (poly Gl) in a single-strand...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1978
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.1.62